Philadelphia Phillies starter Zack Wheeler was removed from Game 6 of the World Series on Saturday night against the Houston Astros after he allowed two base runners in the middle of the sixth inning.

Jose Alvarado would relieve him and the next batter, Yordan Alvarez, would hit a three-run home run to put the Astros up 3-1. Wheeler would eventually get saddled with the loss and get tagged with two earned runs on the home run.

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Zack Wheeler talks with JT Realmuto

Catcher J.T. Realmuto and pitcher Zack Wheeler of the Philadelphia Phillies talk on the mound during the sixth inning against the Astros in Game 6 of the World Series at Minute Maid Park on Nov. 5, 2022, in Houston, Texas. (Carmen Mandato/Getty Images)

Wheeler admitted he was a little thrown when manager Rob Thomson relieved him with one out and runners on first and third. A double play would’ve ended the inning.

"It caught me off guard a little bit," Wheeler told reporters after the game, via ESPN. "It's win or go home right there. That's a tough pill to swallow. It's ultimately Top's [manager Rob Thomson] call and that's the call he made."

ASTROS WIN SECOND WORLD SERIES IN FRANCHISE HISTORY, BEAT PHILLIES IN SIX GAMES

Zack Wheeler unhappy with being pulled from game

Zack Wheeler of the Philadelphia Phillies walks off the field after being pulled from Game 6 of the World Series on Nov. 5, 2022, in Houston, Texas. (Carmen Mandato/Getty Images)

He added: "It was tough. Obviously, I wanted to be out there and make the pitches. That type of stuff is going to happen. Just probably not the game for it to happen in."

Thomson said he thought Alvarado would’ve provided a better matchup against Alvarez.

"I thought Wheels still had really good stuff. It wasn't about that. I thought the matchup was better with Alvarado on Alvarez at that time," Thomson said.

Zack Wheeler pitches in the World Series

Zack Wheeler pitches against the Houston Astros at Minute Maid Park on Nov. 5, 2022. (Carmen Mandato/Getty Images)

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The Astros would win 4-1 and capture their second World Series title.