Peyton and Eli Manning are one of the most famous athlete brothers in the history of the NFL.

Both quarterbacks had incredible NFL careers, and while they did not have much of a rivalry on the field, their ability to annoy the heck out of each other is everlasting. The Pro Football Hall of Famer described a rather recent story of having to fend off his little brother.

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Eli and Peyton Manning at a Yankees game

Eli Manning, of the New York Giants, and Peyton Manning, of the Denver Broncos, appear at the game between the New York Yankees and the Tampa Bay Rays on May 4, 2014 in the Bronx borough of New York City. (Al Bello/Getty Images)

During Monday’s edition of the "ManningCast," during the game between the New England Patriots and Arizona Cardinals, columnist Bill Simmons asked what the biggest fight was the two ever had.

"A couple years ago, we were on a golf trip and I was trying to take a nap," Peyton Manning explained. "And I was kinda in a corner bed and he came up behind me and he kinda had me leveraged into the wall and he gave me a wedgie. He almost went atomic wedgie."

Eli Manning said it definitely was an "atomic wedge," where the underwear goes over the head.

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Eli and Peyton Manning play golf

Former NFL players Peyton Manning and Eli Manning look on from the 11th tee during the second round of the AT&T Pebble Beach Pro-Am at Monterey Peninsula Country Club on Feb. 7, 2020 in Pebble Beach, California. (Harry How/Getty Images)

"I was so angry," Peyton Manning said. "Basically, because the nap was interrupted. The atomic wedge was an added bonus. He was so proud … we almost threw down. I was in pain. I couldn’t fight real well."

The former New York Giants star said what drove his brother even crazier was that it was his "favorite" pair of underwear.

"I totally ripped them off eventually."

Peyton Manning played in the NFL for the Indianapolis Colts and the Denver Broncos during his illustrious career. He was a 14-time Pro Bowler and seven-time All-Pro selection. He won the MVP award five times.

Eli and Peyton Manning December 2022

Former Football Quarterbacks Peyton Manning and Eli Manning talk prior to the SEC Championship game between the LSU Tigers and the Georgia Bulldogs at Mercedes-Benz Stadium on Dec. 3, 2022 in Atlanta. (Kevin C. Cox/Getty Images)

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Eli Manning played for the Giants for his entire career. He was a four-time Pro Bowler, two-time Super Bowl champion and two-time Super Bowl MVP. He finished his career with more passing touchdowns (366) than John Elway, Warren Moon, Johnny Unitas and Dan Fouts, and more passing yards (57,023) than Joe Montana, Jim Kelly and Steve Young.