The Supreme Court on Monday refused to block a New York regulation that requires health care workers to get the COVID-19 vaccine without any religious exemptions. 

The vaccine mandate for health care workers, which went into effect in August, allows only for medical exemptions but not religious ones. The Supreme Court turned away two applications from doctors and nurses in the state for injunctive relief to allow religious exemptions while litigation continues in the lower courts over the mandate's constitutionality.

SUPREME COURT CARSON V. MAKIN ARGUMENTS: JUSTICES OFFER SUPPORT FOR RELIGIOUS RIGHTS IN MAINE EDUCATION CASE

FILE - In this April 23, 2021, file photo members of the Supreme Court pose for a group photo at the Supreme Court in Washington. Seated from left are Associate Justice Samuel Alito, Associate Justice Clarence Thomas, Chief Justice John Roberts, Associate Justice Stephen Breyer and Associate Justice Sonia Sotomayor, Standing from left are Associate Justice Brett Kavanaugh, Associate Justice Elena Kagan, Associate Justice Neil Gorsuch and Associate Justice Amy Coney Barrett. Before the Supreme Court this is week is an argument over whether public schools can discipline students over something they say off-campus. (Erin Schaff/The New York Times via AP, Pool, File)

In this April 23, 2021, file photo members of the Supreme Court pose for a group photo at the Supreme Court in Washington.  (AP)

Justices Clarence Thomas, Samuel Alito and Neil Gorsuch dissented.

Gorsuch wrote in his dissent that the mandate turns away the very doctors and nurses the state has depended on throughout the course of the pandemic.

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"We do all this even though the State’s execu­tive decree clearly interferes with the free exercise of reli­gion—and does so seemingly based on nothing more than fear and anger at those who harbor unpopular religious be­liefs," Gorsuch wrote. 

"We allow the State to insist on the dismissal of thou­sands of medical workers—the very same individuals New York has depended on and praised for their service on the pandemic’s front lines over the last 21 months," he continued. "To add in­sult to injury, we allow the State to deny these individuals unemployment benefits too. One can only hope today’s rul­ing will not be the final chapter in this grim story."

Fox News' Bill Mears and Shannon Bream contributed to this report.