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"Real Time" host Bill Maher had some tough words for Democrats who are circling the wagons around President Biden following his disastrous debate performance. 

"I have said before, I will vote for his head in a jar of blue liquid. After last night, time to get the jar," Maher quipped during the panel discussion Friday night. 

After reiterating his months-long call to replace Biden on the Democratic ticket, he stressed it is now "absolutely apparent" and that it is the "only way" for Democrats to win the election. 

BIDEN'S ‘DISASTER’ DEBATE PERFORMANCE SPARKS MEDIA MELTDOWN, CALLS FOR HIM TO WITHDRAW FROM 2024 RACE

Joe Biden

President Joe Biden walks off stage during the CNN Presidential Debate at the CNN Studios on June 27, 2024 in Atlanta, Georgia. (Justin Sullivan/Getty Images)

"The flash poll after, Trump, they said, won 67 to 33," Maher said. "33, that number rings in my mind. Because you know what that number is? That's the number you always see very close- 33, 34, 32 of the people who are just always with their party. I mean, this is Mrs. Goebbels in the bunker number… You see it on the right. They used to call them birthers, Tea Party, whatever MAGA nation, they never move. And now I feel like that's a third of the Democrats who are, like, they're gonna stick with this guy and they are going to regret it."

"He is going to lose. I said it nine months ago. I'm gonna say it again tonight. And now, it seems like it's so apparent," Maher continued.

MEDIA FIGURES SHOCKED AT BIDEN'S 'BAD' DEBATE PERFORMANCE: ‘TOTAL AND COMPLETE DISASTER’ 

Bill Maher

"Real Time" host Bill Maher said the Left was "aggressively anti-common sense" during an interview with journalist Tina Brown. (Screenshot/HBO)

The liberal comedian then played the infamous clip from the debate where Biden said that his administration "finally beat Medicare." 

"It reminded me of when Mike Tyson used to knock guys out in 90 seconds. Like that was like two minutes into the debate and I went like ‘Oh, this election is over.’ That was like a haymaker," Maher said. 

"I feel like the whole rationale for Biden running has always been 'I'm the only guy who can beat him.' Now I think it's inverted. I think he's the only guy who could lose to him," he continued. "I keep hearing all day from these Democrats defending this. Like, 'we can't abandon Joe Biden.' What about me? I feel abandoned. I feel abandoned. I have nobody to vote for." 

Joe Biden, Donald Trump

President Biden and former President Trump debated on Thursday night.  (Getty Images)

Top Democrats including former President Obama have expressed support for Biden following his questionable performance at Thursday's CNN Presidential Debate.

"Bad debate nights happen. Trust me, I know," Obama said in a statement Friday. "But this election is still a choice between someone who has fought for ordinary folks his entire life and someone who only cares about himself. Between someone who tells the truth; who knows right from wrong and will give it to the American people straight — and someone who lies through his teeth for his own benefit. Last night didn’t change that, and it’s why so much is at stake in November."

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Meanwhile, calls for Biden to withdraw from the presidential race have dramatically grown in the liberal media, most starkly from The New York Times editorial board. 

"Mr. Biden has been an admirable president. Under his leadership, the nation has prospered and begun to address a range of long-term challenges, and the wounds ripped open by Mr. Trump have begun to heal. But the greatest public service Mr. Biden can now perform is to announce that he will not continue to run for re-election," the Times editorial board wrote Friday.