Jennifer Aniston admits she has 'lost' some friends who didn't get the COVID vaccine: 'It's a real shame'

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Jennifer Aniston admitted she's recently lost some friends who "refused" or "did not disclose" their coronavirus vaccination status. 

The 52-year-old actress has been publicly supportive of social distancing, wearing masks to prevent the spread of the virus and getting vaccinated.

"There's still a large group of people who are anti-vaxxers or just don't listen to the facts," Aniston told Instyle in an interview published Tuesday. "It's a real shame."

"I've just lost a few people in my weekly routine who have refused or did not disclose [whether or not they had been vaccinated], and it was unfortunate," she added. 

FANS DEFEND JENNIFER ANISTON FROM BACKLASH TO CORONAVIRUS-THEMED CHRISTMAS ORNAMENT 

Jennifer Aniston nixed some friends from her ‘weekly routine’ who either 'refused' or ‘did not disclose’ their vaccination status to her. (Photo by Leon Bennett/Getty Images)

"I feel it's your moral and professional obligation to inform, since we're not all podded up and being tested every single day," Aniston insisted. "It's tricky because everyone is entitled to their own opinion — but a lot of opinions don't feel based in anything except fear or propaganda."

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Aniston strongly pleaded with her Instagram followers last summer to mask up as the number of cases across the United States continued to grow.

"This simple and effective recommendation is being politicized at the expense of peoples' lives," Aniston wrote about wearing face masks at the time. "And it really shouldn't be a debate."

The "Friends" actress revealed she received the second dose of the coronavirus vaccine on May 7. 

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"We are extremely lucky and privileged to have access to Covid-19 vaccines in the U.S. right now," Aniston wrote in the caption of a photo sharing the news. "Unfortunately, that’s not the case everywhere... and as we know, the health of one of us affects all of us. Thinking about those who do not or will not have the opportunity to get vaccinated and hug their friends and family."