Singer-songwriter Carly Simon’s sisters died one day apart after battling cancer, a representative for Simon confirmed with Fox News Digital.
Broadway composer Lucy Simon was 82, and former opera singer Joanna Simon was 85.
Lucy died Thursday and had suffered from metastatic breast cancer. Joanna Simon died the day before and had battled thyroid cancer, Simon's rep announced.
"I am filled with sorrow to speak about the passing of Joanna and Lucy Simon. Their loss will be long and haunting. As sad as this day is, it’s impossible to mourn them without celebrating their incredible lives that they lived," Carly said in a statement obtained by Fox News Digital.
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"We were three sisters who not only took turns blazing trails and marking courses for one another, we were each other's secret shares. The co-keepers of each other’s memories. I have no words to explain the feeling of suddenly being the only remaining direct offspring of Richard and Andrea Simon. They touched everyone they knew and those of us they’ve left behind will be lucky and honored to carry their memories forward. With great and eternal love and respect," she continued.
In 1991, Lucy received a Tony nomination for her work in the Broadway musical "The Secret Garden."
Carly and Lucy once performed as the Simon Sisters, opening for acts in Greenwich Village folk clubs.
Lucy and her husband, David Levine, produced two Grammy-winning children’s albums, "In Harmony," and "In Harmony 2."
The pair had two children, Julie Simon, and James Levine, along with four grandchildren – Sophie, Ben, Charlie and Evie.
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Meanwhile, in 1962, the former talented singer Joanna made her debut at the New York City Opera as Mozart’s Cherubino, and she continued her career with the New York Philharmonic, the Vienna Philharmonic and the Pittsburgh Symphony Orchestra.
Joanna was a former arts correspondent for PBS’s "MacNeil-Lehrer News Hour" until 1992 and then found a career in real estate.
The three musically talented Simon sisters were the children of publishing giant Richard Simon – founder of Simon & Schuster – and his wife, Andrea, a civil rights activist and singer.
The Simon family had a late younger brother and son named Peter, who died of cardiac arrest at 71 after being treated for cancer.
Carly, the youngest out of the three Simon sisters, is known for her popular hits, including "You’re So Vain," "Anticipation," and "Haven’t Got Time for the Pain."
The Simon sisters were featured in each other’s music projects throughout the years.
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Joanna sang backup on Carly’s 1972 album, "No Secrets," and Lucy’s 1975 album, "Lucy Simon."
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In 1993, Carly also wrote her own opera, "Romulus Hunt," released as an album and featured a character named Joanna, a mezzo-soprano, just like her sister.
The Associated Press contributed to this report.