Tropical Depression Nicole was bringing heavy rainfall to parts of the Southeast early Friday.
The National Hurricane Center said that flash, urban and small stream flooding would be possible across the southern and central Appalachians.
Heavy rain and isolated flooding impacts will extend northward through eastern Ohio, west-central Pennsylvania, western New York and northern New England by Friday night and into Saturday.
Nicole weakened to a tropical depression Thursday night, after causing at least five deaths as it moved through the Sunshine State into Georgia.
NICOLE BATTERS FLORIDA, 2 PEOPLE ELECTROCUTED BY DOWNED POWER LINES
The storm was briefly a Category 1 hurricane when it made landfall in Florida at around 3 a.m. on Thursday. It initially hit Vero Beach before moving through the Orlando metropolitan area and on to the Florida Panhandle.
At least five people died in the storm. The Orange County Sheriff's Office reported that a man and a woman were electrocuted by a downed power line.
Two others in Orange County were killed in a car crash, according to the Florida Highway Patrol. A fifth person, a 68-year-old man, died from an unknown cause while on a yacht in Cocoa Beach.
"When police and firefighters arrived, they found a couple on the boat as it was being battered by the waves and the dock," Cocoa Police Department said on Facebook, adding that the man and his wife were eventually transported to the hospital, where he was pronounced dead.
NASA MOVES ARTEMIS 1 LAUNCH DATE DUE TO APPROACHING TROPICAL STORM NICOLE
Building damage from the storm also prompted evacuations. At least 25 single-family homes in Wilbur-by-the-Sea were deemed unsafe and evacuated, along with 24 hotels and condos in New Smyrna Beach and Daytona Beach Shores.
"Structural damage along our coastline is unprecedented. We’ve never experienced anything like this before," County manager George Recktenwald said during a news conference.
Nicole sent homes — some that had lost protections during Hurricane Ian — toppling into the Atlantic Ocean along the coast, damaging many others.
Nicole also caused flooding well inland, and parts of the St. Johns River were at or above flood stage. Some rivers in the Tampa Bay area also nearing flood levels, according to the National Weather Service.
All of Florida's 67 counties were under a state of emergency due to the storm.
President Biden also approved an emergency declaration for the Seminole Tribe of Florida.
CLICK HERE TO GET THE FOX NEWS APP
The arrival of Nicole marked the third time that a November hurricane has made landfall in Florida's recorded history. The other two November hurricanes were the 1935 Yankee Hurricane and Hurricane Kate in 1985.
The Associated Press contributed to this report.