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President Biden is set to address the nation on Wednesday evening from the Oval Office for the first time since he officially dropped out of the 2024 election. 

"Tomorrow evening at 8 PM ET, I will address the nation from the Oval Office on what lies ahead, and how I will finish the job for the American people," Biden posted to his X account on Tuesday. 

Biden had been self-isolating in Rehoboth Beach, Delaware, since last Wednesday, when he was diagnosed with COVID-19, which forced him to cancel scheduled events in Las Vegas and fly back to his home in The First State. After suffering "mild symptoms" and "general malaise" after his diagnosis, he received a negative diagnosis on Tuesday of this week and returned to the White House. 

His trip back to the nation's capital on Tuesday marked the first time Biden was seen in public since suspending his re-election bid on Sunday and the first time since being diagnosed with COVID-19 on July 17. 

BIDEN ENDS BID FOR 2ND TERM IN WHITE HOUSE AS HE DROPS OUT OF HIS 2024 REMATCH WITH TRUMP

Joe Biden with sunglasses giving thumbs up

President Biden walks to Air Force One at Dover Air Force Base in Delaware on July 23, 2024. (Reuters/Ken Cedeno)

Biden's address Wednesday is expected to shed additional light on his departure from the 2024 race after he, his campaign and the White House vowed for weeks that Biden would remain in the election cycle and was determined to win in the rematch against former President Trump. 

Since the end of World War II, there have only been three incumbent presidents, all Democrats, who turned down running for a second term: Harry Truman, Lyndon Johnson and Biden.

The 46th president had faced mounting pressure from his Democrat allies and legacy media outlets to bow out of the race since June 27, when he delivered a botched debate performance against Trump that was riddled with garbled remarks and where the president lost his train of thought and appeared more subdued than during other recent public events. 

GOP CONGRESSMAN CALLS ON HARRIS TO 'IMMEDIATELY' INVOKE 25TH AMENDMENT OVER BIDEN'S 'DECLINING HEALTH'

The debate reignited concern among conservatives and critics that Biden's mental acuity had slipped, while it marked the beginning of a pressure campaign among Democrats to oust Biden in favor of a candidate they believed is better suited to take on Trump.

U.S. Vice President Kamala Harris delivers remarks as U.S. President Joe Biden looks on

Vice President Harris delivers remarks as President Biden listens at the White House on July 26, 2021. (Anna Moneymaker/Getty Images)

Dozens of members of Congress began publicly thanking Biden for his work in the White House and decades in public office while calling on him to pass the torch to another candidate. He made the announcement just more than a week after an assassination attempt on Trump's life during a rally in Pennsylvania and just days after the Republican National Convention wrapped up in Milwaukee, where Trump was certified as the Republican Party's nominee.

GOP SENATOR DEMANDS CABINET INVOKE 25TH AMENDMENT AGAINST BIDEN AFTER SUSPENDING HIS RE-ELECTION CAMPAIGN 

Donald Trump at RNC

Republican presidential nominee Donald Trump and his running mate, Sen. JD Vance, are shown at the Republican National Convention at Fiserv Forum in Milwaukee on July 16, 2024. (Reuters/Elizabeth Frantz)

Shortly after his announcement on Sunday afternoon, Biden endorsed Vice President Harris to pick up the mantle and make a run for the party's nomination. As of Tuesday, Harris had enough delegates to lock up the nomination, which will be certified by the DNC next month.

TRUMP SAYS BIDEN 'IS NOT FIT TO SERVE': 'WHO IS GOING TO BE RUNNING THE COUNTRY FOR THE NEXT 5 MONTHS?'

Harris is hitting the campaign trail and weighing running mate options as potential contenders such as Kentucky Gov. Andy Beshear, Transportation Secretary Pete Buttigieg, North Carolina Gov. Roy Cooper and others are floated by political pundits. 

Kamala Harris waving from steps to Air Force Two

Vice President Harris boards Air Force Two at Joint Base Andrews, Md., on July 23, 2024. (Reuters/Kevin Mohatt/Pool)

Concerns over Biden's health mounted for years among conservatives and critics, including former White House physician Ronny Jackson sounding the alarm during the 2020 election cycle, ahead of hitting a fever pitch this summer.

"As a citizen, not as a candidate running for Congress but as a citizen of this country, I’ve watched Joe Biden on the campaign trail, and I am concerned and convinced that he does not have the mental capacity, the cognitive ability, to serve as our commander in chief and our head of state," Jackson, who is now a Republican congressman representing Texas, said in 2020. 

'PROUD OF OUR PRESIDENT': DEMS HEAP PRAISE ON BIDEN FOR DECISION TO END 2024 CAMPAIGN

In February this year, Special Counsel Robert Hur published his report investigating the president's handling of classified documents after his departure as vice president in the Obama administration, which fanned the flames about Biden's health concerns. The report stated that Hur would not recommend criminal charges against Biden for possessing classified materials after his vice presidency, calling Biden "a sympathetic, well-meaning, elderly man with a poor memory."

Karine Jean-Pierre in yellow suit at press briefing lectern

White House press secretary Karine Jean-Pierre speaks during the daily press briefing on July 9, 2024. (Jim Watson/AFP via Getty Images)

The Biden administration and former Biden campaign repeatedly shut down any claims that the president was suffering from a disease such as Parkinson's or dementia as concerns mounted between the debate and Biden dropping out. The White House additionally told Fox News Digital on Monday that the president's health did not play a role in his departure from the 2024 race. 

POTENTIAL HARRIS WHITE HOUSE MURKY AS VP 'NEVER EXHIBITED A CORE SET OF BELIEFS': DEM STRATEGIST

Now that the president has dropped out of the election cycle, conservative lawmakers and others have called on Biden to resign from the White House, arguing that if he is unable to run for re-election, he's unfit to run the nation for the roughly five months left of his tenure. 

Speaker Mike Johnson

House Speaker Mike Johnson (Getty Images/File)

"If Joe Biden is not fit to run for President, he is not fit to serve as President. He must resign the office immediately. November 5 cannot arrive soon enough," House Speaker Mike Johnson, R-La., said in a statement on Sunday.

"If the Democrat party has deemed Joe Biden unfit to run for re-election, he's certainly unfit to control our nuclear codes," House Majority Whip Tom Emmer, R-Minn., added. "Biden must step down from office immediately."

10 DEMOCRATS VICE PRESIDENT KAMALA HARRIS COULD NAME AS HER 2024 RUNNING MATE

Trump's running mate, Ohio Sen. JD Vance, also called on Biden to resign hours before he officially announced he was dropping out.

"If Joe Biden ends his reelection campaign, how can he justify remaining President? Not running for reelection would be a clear admission that President Trump was right all along about Biden not being mentally fit enough to serve as Commander-in-Chief. There is no middle ground," Vance tweeted Sunday morning.

Andy Ogles, Tennessee Republican congressman

Rep. Andy Ogles, R-Tenn. (Tom Williams/CQ-Roll Call via Getty Images/File)

Others have called on Harris to invoke the 25th Amendment while concerns mount over Biden's health. Tennessee Rep. Andy Ogles sent a letter to Harris on Thursday requesting she invoke the 25th Amendment, exclusively telling Fox News Digital that Biden left the race "because he isn’t up for the job of president, and everyone in America knows it." 

"I’ve said for over a year that Biden’s ever-declining health has rendered him incapable of leading the nation. With his recent reclusion following a supposed COVID diagnosis, it is now more apparent than ever that he must resign or be forced out. Since Biden has made it clear he will not resign, it is imperative that Vice President Harris move forward with invoking the provisions of the 25th Amendment to remove him forcibly. The safety and well-being of the American people and our nation depend upon it," Ogles said.

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Biden's address on Wednesday will be delivered from the Oval Office at 8 p.m. ET and will focus on his withdrawal from the race and his plans for the remaining months in office.