Rap pioneer Shock G’s cause of death has been determined.

Gregory Jacobs died from a combination of fentanyl, ethanol (alcohol) and methamphetamine, an initial case summary of the legendary emcee's autopsy revealed. The manner of death was ruled accidental, according to the summary from the Hillsborough County Medical Examiner's office. 

Jacobs, 57, was found unresponsive on April 22 in a hotel room in Tampa, Fla., the Hillsborough County Sheriff’s Office reported to the medical examiner. Digital Underground confirmed Jacobs' death to Fox News at the time.

As Shock G, Jacobs led Digital Underground, a hip-hop group with an ever-changing lineup that gave rise to legends like Tupac Shakur, Chopmaster J and more.

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Shock G, a close Tupac collaborator, was found unresponsive on April 22 in a hotel room in Tampa, Fla. (Photo by Johnny Nunez/WireImage)

Shock G, a close Tupac collaborator, was found unresponsive on April 22 in a hotel room in Tampa, Fla. (Photo by Johnny Nunez/WireImage)

He formed the group with Jimi C. "Chopmaster J" Dright Jr. and Kenneth "Kenny-K" Waters in the late 1980s. The group featured a new lineup with each album and tour.

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Shakur performed on Digital Underground's 1991 song "Same Song" and appeared in the music video.

Jacobs and Shakur remained close collaborators, and Jacobs reportedly helped produce Shakur's debut solo album, "2Pacalyse Now." Furthermore, Shakur's "I Get Around" features Jacobs.

Gregory 'Shock G' Jacobs of Digital Underground died of an accidental overdose on April 22, 2021, an initial case summary from the Hillsborough County Medical Examiner's office revealed.  (Photo by Earl Gibson III/Getty Images)

Gregory 'Shock G' Jacobs of Digital Underground died of an accidental overdose on April 22, 2021, an initial case summary from the Hillsborough County Medical Examiner's office revealed.  (Photo by Earl Gibson III/Getty Images)

With Digital Underground, Jacobs was known best for his work on the song "The Humpty Dance."

Dright shared a throwback photo of himself and Jacobs on Instagram at the time to pay tribute to his friend.

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"34 years ago almost to the day we had a wild idea we can be a hip hop band and take on the world through it all the dream became a reality and the reality became a nightmare for some," the musician wrote alongside a black-and-white photo of himself and his collaborator. "And now he’s awaken from the fame long live shock G Aka Humpty Hump and Rest In Peace my Brotha Greg Jacobs!!!"

Fox News’ Nate Day contributed to this report