A Baltimore area bus crashed into a building Saturday afternoon, causing mass casualties, according to various reports.

The bus, carrying an unknown number of passengers at the time of this report, is said to have crashed into a building at 500 W Franklin St. in central Baltimore. Two other vehicles were involved, according to local news reports.

Initial reports suggested that the bus collided with a Lexus model automobile at the intersection of North Paca Street and West Mulberry Street in Central Baltimore. 

Emergency responders reported an initial 17 injured in need of care and requested an additional five medics, according to Baltimore Metro News.

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An image shows the MTA bus crashing into the building

MTA Bus crashes into building at 500 Franklin St in Baltimore, MD (WBFF)

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Image of 500 W Franklin St

500 W Franklin St. in central Baltimore (Google Earth)

An image shows the MTA bus crashing into the building

MTA Bus crashes into building at 500 Franklin St in Baltimore, MD (WBFF)

Two of those injured are in serious, possibly life-threatening condition, local reports stated. 

Following the incident, emergency responders declared the scene to be a Level 1 Mass Casualty Incident (MCI) and requested additional resources to assist at the scene. 

An image shows the MTA bus crashing into the building

Debris from the bus crash at 500 Franklin St in Baltimore, MD (WBFF)

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Police are investigating the incident.