Louisville, KY – Caroline Doty had 15 points and No. 3 46, at KFC Yum! Center on Tuesday.
Tiffany Hayes and Bria Hartley scored nine points apiece for Connecticut (22-2, 10-1 Big East) which has won 10 straight and will take on No. 14 Georgetown on Saturday.
Shoni Schimmel had a game-high 20 points to go with eight rebounds and Sara Hammond added 10 points for Louisville (17-7, 6-5) which has lost its last three contests.
UConn went on a 24-4 run over a 10-minute span in the first half to take a 33-17 lead into halftime.
Louisville would get within six after Schimmel knocked down a jumper with just over five minutes to play, but Harley hit a big three-pointer on the next possession to extend the Huskies' lead and Louisville never recovered.