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Allen Park, MI (SportsNetwork.com) - Detroit Lions running back Reggie Bush is questionable for Sunday's game against the Arizona Cardinals.

Bush, who aggravated a sprained ankle in last week's win over the Miami Dolphins, was held out of practice this week.

The 29-year-old Bush has carried the ball 53 times for 191 yards and one touchdown in seven games this season. The USC product has also caught 26 passes for 169 yards.

If Bush can't play, Joique Bell will get the bulk of the work in the backfield, with Theo Riddick playing a backup role.

Right guard Larry Warford and defensive tackle Nick Fairley are out with knee injuries.