HOUSTON — Gerrit Cole pitched another playoff masterpiece and the Houston Astros jumped to a quick lead, turning back the Tampa Bay Rays 6-1 Thursday night in Game 5 to set up a titanic showdown with the New York Yankees in the AL Championship Series.

After fellow aces Zack Greinke and Justin Verlander were unable to close out the scrappy Rays on the road, Cole made sure Houston moved on. Given a 4-0 cushion in the first inning, he dominated through the eighth in the decisive game of the AL Division Series, striking out 10 and allowing just two hits.

On deck, the heavyweight matchup so many fans wanted to see: Jose Altuve and the 107-win Astros against Aaron Judge and the 103-win Yankees. Game 1 is Saturday night in Houston — the Astros won four of seven meetings this season.

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Houston Astros starting pitcher Gerrit Cole (45) reacts after an out against the Tampa Bay Rays during the seventh inning of Game 5 of a baseball American League Division Series in Houston, Thursday, Oct. 10, 2019. (Associated Press)

Michael Brantley and Altuve put the finishing touches on this victory, hitting back-to-back home runs in the eighth. The Astros advanced to their third straight ALCS, and are aiming for their second World Series crown in that span.

Houston beat the Yankees in a seven-game ALCS on the way to its first championship in 2017. The Astros also won the 2015 AL wild-card game at Yankee Stadium.

The Rays beat Oakland in the AL wild-card game, then took the last two against the Astros to extend their first playoff run since 2013.

But facing Cole, they were in trouble — especially after Altuve, Alex Bregman and the Astros scored four times in the first against Tyler Glasnow.

Cole followed his 15-strikeout gem in a Game 2 win with another overpowering effort. The right-hander, who grew up a Yankees fan and was originally drafted by them but didn't sign, improved to 18-0 in his last 24 starts.

Cole topped the majors with 326 strikeouts this season, led the AL with a 2.50 ERA and posted 20 wins, one behind Verlander for most in the big leagues.

The 29-year-old struck out the first two batters in the eighth before Willy Adames grounded out to end Cole's night. He beat his chest once before walking to the dugout to a huge ovation from the rowdy sellout crowd of 43,418 at Minute Maid Park.

After winning an MLB-best and franchise-record 107 games in the regular season, the Astros were determined not to suffer the same fate as the Dodgers, winners of 106 games, who were ousted from the playoffs by the wild-card Nationals on Wednesday night.

Houston had been outscored 14-4 in the last two games, but looked sharp at home, where it went 60-21 in the regular season.

A day after the Cardinals scored a postseason-record 10 runs in the first inning of a 13-1 win over the Braves, the Astros scored four runs fast. Now it wasn't nearly as big as what St. Louis did, but after the Astros were shut down at Tropicana Field, it was just as huge for them.

The Astros will make their seventh appearance in an LCS and are the first team to reach the ALCS three seasons in a row since the Detroit Tigers did it from 2011-13.

Altuve's shot gave him 11 postseason homers to pass Chase Utley for most all-time by a second baseman.

Cole extended his major league record by striking out at least 10 batters for the 11th straight game, a stretch where he's fanned 135.

Cole pitched a 1-2-3 third but didn't strike anyone out in the frame, ending a streak of 73 consecutive innings with at least one strikeout. The streak, which dated back to Aug. 1, was the longest such streak since 1961, besting the second-best stretch by 33 innings.

George Springer and Brantley hit back-to-back singles and Altuve's single made it 1-0. Bregman's double, which landed just in front of the bullpen in right-center, scored two more to push the lead to 3-0.

Yuli Gurriel's groundball single to left field added another. Houston's five hits and four runs set franchise playoff records for most hits and runs in the first inning.

Eric Sogard hit a solo homer in the Tampa Bay second in his first start in almost a month while dealing with a foot injury. But Tampa Bay managed only a single by Ji-Man Choi in the fourth and a walk by Travis d'Arnaud to start the seventh against Cole.

Roberto Osuna pitched a hitless ninth to finish off the win.

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Rays manager Kevin Cash had said he thought Glasnow could throw about 90 pitches in this one, but he'd seen enough of the big right-hander after 40 pitches and lifted him with two outs in the third for Blake Snell.

Snell, the 2018 AL Cy Young Award winner, got the next four outs in his second career relief appearance after getting the save in Game 4. The Rays wound up using nine pitchers.

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Greinke, who took the loss in Game 3, is likely to start for Houston in Game 1 of the ALCS.