The drama following five siblings trying to get by after the death of their parents was all the rage in 1994.
The show was known equally for its flannel shirts as it was for stars Scott Wolf and Jennifer Love Hewitt, who played love-struck teens.
Check out what they are doing nowadays.
(AP)
Fox played the family patriarch, Charlie Salinger, who was trying to balance parenting his younger siblings and running a restaurant while still having a love life.
He was sensitive and responsible, but in way over his head.
(AP)
Nowadays, Fox is better known as Dr. Jack Shehard from "Lost."
When the hit drama ended earlier this year, Fox admitted that he was done with TV for awhile.
"I won't be doing any more television," the 43-year-old star said. "I've done two six-year shows, about 300 hours of television... I'm done with that."
The father of two wants to spend more time with his family instead. "My family will move to Oregon, back to the country I love," he told "US Magazine" of his plans to relocate.
"I miss the four seasons climate. We're building a house up there and I'll be closer to my brothers and my mother," he says. "Our kids will be closer to their first cousins."
(AP) (��� 2010 American Broadcasting Companies, Inc. All rights reserved.)
Hewitt played Bailey's love interest, Sarah, for four seasons and became every young boy's dream come true. She was sweet, innocent, naive and cute.
After a few episodes in season six, she was written off the show to star in a spin-off called "Time of Your Life." It was cancelled during it's first season.
(AP)
The 31-year-old has appeared in many movies since leaving the hit drama. For the last five years, she's been back on the small screen as the lead in "Ghost Whisperer."
After several high profile romances - including dating Carson Daly and Jamie Kennedy - Hewitt wrote a book called, "The Day I Shot Cupid," that was released in March 2010. The book talks about her failed relationships and something else that's quite personal - her personal grooming.
"After a break up, a friend of mine Swarovski crystalled my 'precious lady' and it shined like a disco ball," she said. "So I have a whole chapter in there about how women should va-jazzle their va-jay-jays."
See, not quite so innocent anymore...
(Maxim)
London played Julia Salinger's (Campbell) boyfriend and then husband. He came on in season two and became a more permanent fixture in later seasons.
(AP)
After playing Griffin, London went on to star as a young minister on "7th Heaven." He's been on several TV shows since then.
Most recently he's been in the headlines describing his alleged kidnapping on June 10th. The 37-year-old, who claims he was held captive for 12 hours, said he was held at gunpoint and forced to "use illicit drugs."
His alleged kidnapper's lawyer <a href="http://www.foxnews.com/entertainment/2010/06/21/exclusive-man-jailed-kidnapping-jeremy-london-claims-partied-night/" target="_blank">denied the charges to FOX411.com</a>.
Stay tuned on that one...
(AP) (AP2009)
Chabert played the young and always inquisitive, child prodigy, Claudia Salinger. Although she was one of the youngest, she was often the one lending advice to her older siblings.
(AP)
The sexy brunette has come a long way from playing the young innocent Salinger. She played an obnoxious teen in "Mean Girls" and Matthew McConaughey's sister-in-law in "Ghosts of Girlfriends Past."
The 27-year-old also guest-starred on an episode of "Ghost Whisperer" with "Party of Five" co-star Jennifer Love Hewitt.
(Maxim)
Campbell played Julia, an over-dramatic, overly sensitive, love-struck teen who always seemed to be between boyfriends.
(AP)
The young actress hit the big screen when the show's run ended in 2000. She starred in the "Scream" horror trilogy and "Wild Things."
In 2009, she returned to TV with a recurring role on "The Philanthropist."
This past April, Kevin Williamson, the screenwriter of the "Scream" franchise confirmed that Campbell will be appearing in another one of his movies that's scheduled to be released in April 2011.
(AP)
Wolf played the family's problem solver, Bailey Salinger. He quickly became a heartthrob to young girls, as the rebellious teen.
At one point the family even had to step in to confront him about his substance abuse problems.
(AP)
Wolf has appeared on many shows including, "Spin City," "Everwood," and "Nine." Most recently he's been starring in the new sci-fi show, "V."
In May 2004, Wolf married Kelley Limp from "The Real World: New Orleans." They welcomed their first child, Jackson Kayse, on March 22, 2009.
(REUTERS)