This drama captured the early '90s with teenaged angst, crazy outfits, mullets and annoying jocks all included.
The show, which ran from 1990-1995, centered around the Russo family which consisted of Blossom, her single dad and two older brothers, Tony and Joey.
Tony was a recovering alcoholic turned paramedic, while Joey was the epitome of a dumb high school jock whose famous "whoa" made girls swoon.
And who could forget her BFF Six, the fast-talking ditzy teen with a crazy sense of style.
Let's take a look back at where these '90s stars are today, shall we?
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Mayim will perhaps forever be known as "Blossom."
Blossom's unique style set her apart, and she was usually the lone voice of reason in a house full of men.
There was always drama, whether it was with her brothers, best-friend Six, or her on-again, off-again relationship with Vinnie.
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After the show ended, Mayim spent years doing voice over work for "The Real Adventures of Johnny Quest" and "Recess."
After doing several other shows, the 34-year-old actress has made her way back to prime-time TV with a recurring spot as Sheldon Cooper's nerdy girlfriend on "The Big Bang Theory."
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Joey was the epitome of a dumb jock who had a long drawn out "whoa."
He could be sweet and smart if he really tried, but that didn't happen too often.
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The 34-year-old actor has long lost his '90s surfer hair.
In 2006 he made fans say, "Whoa!" when he sashayed across the dance floor on "Dancing with the Stars." He currently stars on the ABC Family comedy, "Melissa & Joey."
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Jenna played Six, who was a permanent figure in the Russo household. The fast-talking teen always had boy drama and an unmistakable crush on Blossom's older brother Joey.
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Jenna has tried to change her image repeatedly since the end of "Blossom."
At first she went to film school for two years, but she returned to acting and appeared on "The Parkers" from 1999 to 2004.
The 33-year-old, who has always been interested in pursuing a music career, released her debut album, "Breathing Room" in 2007.
On Oct. 10, the aspiring musician married long-time beau Brad Bratcher in an intimate ceremony in her hometown, Newton, CT.
"We're so happy," she later gushed to People. "My mama told me never to meet a man at a bar – so I did!"
The couple met at a wine bar two years ago and got engaged New Years Eve 2010.
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Michael played Tony, a guy who turns his life around after a four year battle with substance abuse.
He goes from working at a donut shop to becoming a paramedic.
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Michael left "Blossom" to write for "Late Night with Conan O'Brien." After a few other writing gigs he went back to acting with small parts here and there.
He made a surprise appearance with a small role in "The Dark Knight" in 2008.
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Ted played Blossom's father Nick Russo. After his wife leaves him, he's stuck raising their three kids on his own.
He was often seen on the piano working on his music and going off to play gigs.
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After acting as a dad for five years Ted set his sights on directing and hasn't really been seen on camera since.
He has directed episodes of "Melissa & Joey" (with his former TV son, Joey Lawrence), "Accidentally on Purpose" and "The Big Bang Theory."
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In May 2010, several members of the cast of "Blossom" reunited for one of the final episodes of "'Til Death."
“It was really fun,” Mayim said of the reunion. “There were people I knew very well that I had not seen in years.”
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