Updated

A chemical plant in northeastern Spain exploded Tuesday evening, killing one person and injuring at least nine people, authorities said.

A tweet by emergency services for the Catalonia region earlier called the massive blast in the port city of Tarragona a "chemical accident."

The interior minister of Spain's Catalonia region, Miquel Buch, tweeted that one person remained missing. Emergency services said medics were treating two of the injured for major burns.

Smoke rising after the explosion at the industrial hub near the port city of Tarragona, Spain, on Tuesday.

Smoke rising after the explosion at the industrial hub near the port city of Tarragona, Spain, on Tuesday. (AP)

The civil protection agency was advising people living in parts of the city of 800,000 and in nearby towns to close their windows and to refrain from going outside as preventive measures.

Videos showed the aftermath of the blast, with flames and a big column of black smoke emerging from an area dotted with big industrial tanks. Fire departments sent 24 brigades to the area, the regional emergency service said.

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Some people in the area told Tarragona Radio that they could hear the blast from miles away.

Tarragona is about 71 miles southwest of Barcelona.

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Since 2015, the city has housed a 2,965-acre "chemical hub," ChemMed, that was described as the largest of its kind in southern Europe.

This is a developing story. Check back for updates.

The Associated Press contributed to this report.