Nancy Guthrie search: Family pleads for 'way to communicate' with captors as first deadline passes

Click here to follow the latest updates in the search for Nancy Guthrie.

Pima County Sheriff Chris Nanos urged people not to use the agency's non-emergency phone line to offer thoughts and prayers for Nancy Guthrie's family, saying authorities need the line to remain open for investigative purposes as they continue probing the abduction of the 84-year-old woman.

"The Pima County Sheriff's Department understands that many people want to share their thoughts and prayers with the family of Nancy Guthrie, and we appreciate the community's support," the sheriff said in a statement posted to X.

"We respectfully ask that these messages be shared on social media and not through the PCSD non-emergency phone line," he continued. "Calls expressing condolences have overwhelmed our communications staff, and it's critical that the line remain available for law enforcement purposes."

"Thank you for your understanding and cooperation as we continue to serve the community," Nanos added.

Arizona Gov. Katie Hobbs said on Thursday that her heart was with the Guthrie family and that state authorities were working with local police after Nancy Guthrie, 84, was kidnapped from her home near Tucson.

"My heart is with the Guthrie family," Hobbs said on X.

"The Arizona Department of Public Safety is coordinating with local law enforcement in Tucson, offering Rapid DNA analysis and prepared to deploy additional support as needed," the governor added.

Security has been bolstered at NBC’s Today show studio in New York after co-host Savannah Guthrie’s mother, Nancy Guthrie, was kidnapped from her home in Arizona.

The increased security comes out of an abundance of caution after Nancy Guthrie disappeared nearly a week ago, according to The Hollywood Reporter.

The police and private security presence at 30 Rockefeller Plaza, where NBCUniversal also has offices, is typically already strong, as the area is popular with tourists and shoppers.

The boosted security is expected to continue until Nancy Guthrie is found, as her daughter and others at NBC are heartbroken over the abduction, according to the report.

Law enforcement was spotted Thursday afternoon canvassing Annie Guthrie's neighborhood, days after her 84-year-old mother, Nancy, was seemingly abducted from her Tucson home.

Nancy Guthrie was last seen with family members Saturday night, and reported missing by family members the following day.

Officers were caught on video Thursday afternoon in her daughter Annie's neighborhood, knocking on doors, entering homes and asking about security cameras and video footage. 

The Pima County Sheriff's Department said it has not yet ruled out anyone in relation to her disappearance.

An Arizona news anchor who read an alleged ransom note tied to the disappearance of NBC "Today" co-host Savannah Guthrie's mother, Nancy, described the letter as “detailed,” expressing concern about authorities’ ability to track down the sender.

KOLD anchor Mary Coleman told Fox News’ Griff Jenkins on “The Will Cain Show” Thursday afternoon that the station received a ransom note mentioning Guthrie through its main tip line.

“We take all of them with a grain of salt, but upon reading it and seeing some of those details that perhaps others might not know, … the amount that they were requesting and things like that, we were pretty alarmed pretty quickly,” Coleman said.

Coleman explained she could not share the consequences outlined in the letter if authorities miss the first 5 p.m. Thursday deadline or the second Monday deadline, but said the note “implies that something needs to be done in order to meet that timeline.”

She added she was curious if authorities would release more details about the note, as the sender did not provide a way to communicate with them.

“I think … [the inability to contact the suspected captors] is the main reason that they're coming out with this,” Coleman said. “I'm sure you saw the video from Savannah and her family last night, and they are saying, ‘we're ready to talk.’ I think they're trying to build that bridge between whoever, or what people, have done this, so that they can build a line of communication.”

KOLD reportedly submitted all of the information it had to the Pima County Sheriff's Department.

Dr. Gregory Vecchi, retired supervisory Special Agent and Chief of the FBI Behavioral Science Unit, emphasized that any proof-of-life verification in Nancy Guthrie’s disappearance would require additional confirmation due to the rise of artificial intelligence. 

“AI can copy things and it can be very, very realistic in terms of putting things out that appear to be real, that are not,” Vecchi told Fox News Digital. 

For that reason, Vecchi said that law enforcement would likely turn to other methods to verify Nancy Guthrie is alive, in the event her family receives some sort of photo or video verification. 

“You basically would ask the kidnappers, or whoever you're talking to, about something that only Nancy would know,” Vecchi explained. 

“For example, ‘What was my favorite present that I got on my fifth birthday?’ There's no way AI is going to be able to guess that.” 

Vecchi added that law enforcement would have to ask Nancy Guthrie’s abductors a specific question that could not be answered through social media or surveillance as a way to verify the 84-year-old mother is alive and truly in the custody of the individuals responsible for the ransom note.

The video released by NBC "Today" co-host Savannah Guthrie and her siblings on Wednesday afternoon contained a line from the movie "The Silence of the Lambs."

In the video released by Savannah Guthrie and her siblings, Guthrie can be heard saying: "Talk to her, and you'll see."

The same line, "Talk to her, and you'll see," was spoken by Senator Ruth Martin in "The Silence of the Lambs."

“That goes back a while, ‘Silence of the Lambs,’” Dr. Ann Wolbert Burgess, who pioneered the FBI's Behavioral Science Unit, told Fox News Digital. “Which makes you wonder if they have any inkling of an abductor – plural, because I don't think it was just one. But they're maybe thinking of an age range for the abductors.”

“I think they're trying to get some profile that they are comfortable with. I don't think they have it yet, but they're working on it.”

Fox News Digital's Julia Bonavita contributed to this report.

The missing 84-year-old mother of NBC's "Today" anchor Savannah Guthrie lives only one hour north of a Border Patrol checkpoint close to the U.S. border with Mexico.

Just over 50 miles south of Nancy Guthrie's home in the swanky Catalina Foothills area of Tucson, and nearly due south on I-19, lies the Border Patrol checkpoint in the desert town of Tubac.

The checkpoint is in the northbound lane. Southbound traffic moves unimpeded.

Only 25 miles south of that, the United States is separated from the Mexican state of Sonora by an official Border Patrol port of entry in the town of Nogales.

The Sinaloa Cartel holds significant control and influence over Sonora.

Pima County Sheriff Chris Nanos said Thursday there are no suspects or persons of interest in the disappearance of Nancy Guthrie, noting authorities are "actively looking at everybody we come across in this case."

Nanos said Guthrie's family has been "very cooperative," and has "done everything we've asked of them," but officials have not yet ruled them out.

Members of the Guthrie family include:

Annie Guthrie: Nancy's eldest daughter is Annie Guthrie, a poet and jeweler who was once the marketing director at the University of Arizona Poetry Center, according to a 2013 profile in Women's Quarterly.

Tommaso Cioni: Annie is married to Italian-born Tommaso Cioni, an AP biology teacher at BASIS Oro Valley in Tucson. According to his LinkedIn page, he has worked at the school for more than 15 years.

Savannah Guthrie: Nancy's second daughter is prolific journalist and NBC's "Today" host Savannah Guthrie. She has worked as a broadcaster at cable stations in Montana, Missouri, Tucson and Washington, D.C. She also worked briefly in white collar criminal defense and later as a clerk in the U.S. District Court for the District of Columbia before returning to journalism.

Mark Feldman: Mark Feldman, Savannah's husband, is a former Democratic political aide who worked in the Clinton-Gore White House. He worked as senior advisor and traveling chief of staff to Gore, according to People. He is now a business consultant and founding partner of FGS Global, an international communications, consulting and advocacy firm.

Charles Camron Guthrie: Charles Camron Guthrie is the brother of Annie and Savannah. He is a retired military colonel and military colonel who flew F-16s, according to a 2018 Instagram post from Savannah.

Click here to read the full story from Fox News Digital's Peter D'Abrosca.

A ransom note allegedly tied to the abduction of NBC "Today" co-host Savannah Guthrie's mother, Nancy, in Tucson, Arizona, lists two deadlines, the latter of which TMZ says is "much more serious."

The first deadline is 5 p.m. Thursday, the FBI confirmed. The second deadline is Monday.

"TMZ Live" hosts Harvey Levin and Charles Latibeaudiere said the alleged ransom note was sent to their newsroom and lists demands that change with each deadline.

The hosts noted something is "triggered" at each time limit.

Though TMZ did not specify what was in the letter, the outlet reported the second deadline is "much more serious."

The Guthrie family posted a video on social media Wednesday afternoon, about 24 hours before the first deadline, pleading with captors to communicate with them and ensure Nancy Guthrie's safe return.

White House press secretary Karoline Leavitt on Thursday described the apparent abduction of NBC "Today" co-host Savannah Guthrie's 84-year-old mother, Nancy Guthrie, as "heartbreaking."

"The president and I were watching the press conference about the search for Savannah Guthrie's mother, which is just a heartbreaking situation," Leavitt said during a White House news conference. "The president, as you all know, spoke directly with Savannah yesterday, and told her that the federal government is here to help."

She added any requests that are made by state and local officials in the search for Nancy Guthrie will "absolutely be accommodated."

The Trump administration also spoke directly with the FBI on Thursday regarding the case.

"Our hearts and our prayers are with Savannah and her entire family as they search for her dear mother," Leavitt said.

The FBI confirmed a ransom note tied to the Nancy Guthrie missing person case had a deadline listed for 5 p.m. Thursday.

It is unclear if the note listed the deadline in Eastern Time or Mountain Standard Time—the time zone for Tucson, Arizona, where Guthrie disappeared.

Authorities declined to provide any additional information about the contents of the ransom note.

Pima County Sheriff Chris Nanos provided more information Thursday about the timeline surrounding the disappearance of Nancy Guthrie around Tucson, Arizona. 

"About 5:32 p.m. these are approximate times, 5:32 p.m., Nancy travels to her local family's home for dinner and playing games with the family. Just visiting. At 9:48 p.m., which is very consistent to what we were told by the family, that Nancy was dropped off at home and we know that because we have a garage door open at approximately, I can't stress that enough, at approximately 9:48 p.m. At 9:50 p.m., that garage door closes, which at that time we assume that Nancy's home and probably going to bed,” Nanos said. 

“Sunday morning, early morning at 1:47 a.m., the doorbell camera disconnects. At 2:12 a.m., software detects a person on a camera, but there's no video available. They had no subscription and therefore it would rewrite itself, cut up. It just kind of loops right and covers up. That's what our analysis teams have told us,” Nanos continued. “We're not done with that. We'll do all we can. But that's what it says. So it detects a person on camera, could that be an animal? I imagine that's possible. We don't know that. We just have no video. But we're not giving up on that.” 

"Two twenty-eight, Nancy's pacemaker app shows that it was a disconnect from the phone. And at 11:56 a.m., the family checks on Nancy, discovers her missing, and at 12:03 p.m., 911 is called in to the Pima County Sheriff's Department,” Nanos added. 

“I believe it's about approximately ten minutes later, 12 minutes later, our patrol teams arrive. They see the scene and we start our response with our search and rescue teams and our detectives from homicide and various units,” Nanos also said. 

Pima County Sheriff Chris Nanos emphasized during a Thursday afternoon press conference that there is no specific suspect or person of interest in Nancy Guthrie's disappearance, and that authorities are looking at "everybody."

A reporter had asked about online speculation suggesting Tommaso Ciolo, Nancy Guthrie's son-in-law and the husband of her daughter, Annie, has been identified as the primary suspect. Authorities have not accused Ciolo of any wrongdoing at this stage.

"Nobody's eliminated, but we just really don't have enough to say this is our suspect. This is our guy, we know, or our gal. We just don't know that,” Nanos later said. "And it's really kind of reckless to report that someone is a suspect when they could very well be a victim."

"We're actively looking at everybody we come across in this case, everybody. We would be irresponsible if we didn't talk to everybody -- the Uber driver, the gardener, the pool person, whoever. Everybody –- it's so cliche -- but everybody's still a suspect in our eyes. That's just how we look at things and think as cops,” he added.

“And the family's been very cooperative. They've done everything we've asked of them. And we want that relationship to continue,” Nanos also said

FBI Special Agent in Charge of the Phoenix Field Office Heith Janke said on Thursday during an early afternoon press conference that one person has been arrested for making a fake ransom demand as authorities continue their search for Nancy Guthrie.

"My next message is to those imposters who are trying to take advantage and profit from this situation," he said. "We will investigate and ensure you are held accountable for your actions."

"We have made one arrest related to an impostor ransom demand, and a complaint will be presented to a magistrate judge later today," Janke told the media.

He said that the U.S. Attorney's office in Arizona will provide further information on the arrest at a later time.

Pima County Sheriff Chris Nanos said Thursday that, “I wouldn't say anybody's ruled out yet,” in the search for person or persons behind the disappearance of Nancy Guthrie. 

“We've talked to so many. I'm sure that my investigators have feelings about this one's clear, or this one isn’t. But no, I wouldn't say anybody's ruled out yet, because what if I rule you out and then later I learned something else.” 

The FBI announced a $50,000 reward Thursday for information in the Nancy Guthrie disappearance case. 

"The FBI is now working this case jointly with the Pima County Sheriff's Department, and we're going to start today by announcing a $50,000 reward for information leading to the recovery of Nancy Guthrie and or the arrest and conviction of anyone involved in her disappearance,” FBI Phoenix Special Agent in Charge Heith Janke said at a press conference.  

“The FBI has agents, analysts and professional staff employees working day and night with our partners at the Sheriff's Department,” Janke said. 

"We have deployed additional intelligence and agents from our Phoenix office. We have brought in our Critical Incident Response Group from Quantico, Virginia,” he continued. “Members from our Cellular Analysis survey team are here, and they continue to collect and process digital information. We are actively reviewing and analyzing information from all digital sources, which includes banks, social media companies, phone companies, and any other organizations where a digital footprint could have been captured." 

Pima County Sheriff Chris Nanos said Thursday that, "at this time, we have not identified a suspect or a person of interest in this case.”

“We are working our best to do that. But to be clear, we have nobody of interest or any suspects that you would consider a prime suspect,” Nanos said. “We're just not there. We're not there yet."

Pima County Sheriff Chris Nanos said Thursday that DNA test results in the search for missing Nancy Guthrie "were minimal." 

“We're waiting for lab reports. But even then, when they come back quickly, for example, some DNA, we rushed what we thought was the best target for DNA. We did a rush through and got some of that back. The results were minimal," Nanos said. 

"I think you all know of the blood on the porch. That was one we did, it came back to Nancy,” he added. "But there's still more items that have been submitted, we just haven't got them back yet.” 

Pima County Sheriff Chris Nanos said Thursday that, “Right now, we believe Nancy is still out there.” 

“We want her home, our department, the sheriff's department, along with all of our partners at the FBI, have been working around the clock, and we just want her home and find a way to get to the bottom of all of this, just as you do,” Nanos told reporters at a press conference about the search for missing Nancy Guthrie. 

Nanos also reacted to a video posted by the Guthrie family last night, pleading for their mother’s return. 

“We saw last night the family, you know, they just hurt. Understandably so. And so I really want you to know, this entire team here, those behind me and our community are hurting with you. We really just want mom back, okay?” Nanos said. 

Pima County Sheriff Chris Nanos is set to hold a press conference at 1 p.m. ET as authorities investigate Nancy Guthrie's possible abduction from her Arizona home.

It is the first update from Nanos in two days. 

Nancy Guthrie, 84, was last seen at her Tucson home at around 9:30 p.m. Saturday, according to the Pima County Sheriff's Department.

Two news outlets received possible ransom notes relating to Nancy Guthrie's disappearance, which reportedly contain "sensitive information" that may only have been known to the person who took her.

Nancy Guthrie, 84, was last seen at her Tucson home at around 9:30 p.m. Saturday, according to the Pima County Sheriff's Department.

While officials didn't initially elaborate on the circumstances of her disappearance, Sheriff Chris Nanos said on Monday that "we do, in fact, have a crime." A law enforcement source told Fox News Digital that there were "blood drops" leading from the entryway outside down the house's pathway towards the driveway. 

A Pima County Sheriff's Office official told Fox News Digital on Monday that officials believe Nancy Guthrie was either kidnapped or abducted.

Following Tuesday's news conference by the Pima County Sheriff's Department, TMZ and Tucson's CBS affiliate both reported receiving possible ransom notes related to Nancy Guthrie. The Pima County Sheriff's Department said it was "aware" of the possible ransom note and would be investigating it further.

TMZ reported receiving a possible ransom note that demanded millions of dollars be sent in cryptocurrency to a specific Bitcoin address. The note allegedly contained a deadline. The note TMZ received reportedly contained "an element of ‘or else.’"

While TMZ initially reported the alleged note said Nancy Guthrie was wearing a specific item of clothing, it later clarified that the note says she wasn't wearing it.

The possible ransom note, which was given to the Pima County Sheriff's Department, also described an item at Nancy Guthrie's home that was apparently damaged.

Former FBI Assistant Director Chris Swecker told “FOX & Friends First” on Thursday that he believes those behind the disappearance of Nancy Guthrie are “opportunists.” 

“They strike me as opportunists in this case because the ransom demand comes in two days later... instead of a private negotiation with the family and an arrangement to get the Bitcoin, it just seems kind of haphazard,” Swecker said. 

He said the video plea that the Guthries released Wednesday “was done at the advice of, I’m sure, of the FBI.” 

“They made it a point to say in the video here that AI and social media can doctor up images and voices, they made a point to tell if in fact there is a kidnapper out there, ‘look we’re not so sure and if you are real then give us a sign that you are real’ with validation that only the victim would know, things that only the victim would know,” Swecker continued. 

“I think the family had some advisors, private advisors, attorneys, whatever – helping them along as well and just sort of giving them a second look at things and making sure that what they are doing is the right path to take,” he added. 

“Kidnappings -- if it is real – they're gut-wrenching situations,” Swecker said. “But it's actually a positive development in the sense that she might be alive.” 

Fox News' John Roberts, who lives with a pacemaker, gave context as to how missing Nancy Guthrie's heart device might be used by investigators to try and locate her.

Nancy Guthrie was last seen at her Tucson, Arizona home when she was dropped of by family at the house after dinner at around 9:45 p.m., according to Pima County Sheriff Chris Nanos.

NBC's "Today" show reported that Nancy Guthrie's pacemaker appears to have disconnected from its monitoring application during the early morning hours on Sunday.

Nanos said Nancy Guthrie didn't attend her church service, adding that her family was notified about the absence by a churchgoer. Officials said family members went to Nancy Guthrie's home at around 11 a.m. and spent some time looking for her before calling 911 at around noon.

Roberts said that his pacemaker connects to an application on his phone through Bluetooth and has a range of about 100 feet, adding that it doesn't connect to a cell tower.

If the pacemaker is out of range, the connection to the phone is lost.

"If [Nancy Guthrie's] pacemaker is anything like mine, it would tell investigators the moment the phone lost communication with the pacemaker," Roberts said. "As soon was she was abducted, if the phone was left in her home...she would lose that connection."

Roberts said investigators may be able locate Nancy Guthrie if they brought the phone within 100 feet of the pacemaker.

Jim Clemente, a former FBI profiler whose illustrious 22-year career involved working to capture Ted Kaczynski, described Nancy's Guthrie's disappearance as a "targeted event" and said that the perpetrator likely has a connection with the 84-year-old victim.

"The fact that the victim, Nancy Guthrie, was at her home — in the privacy and security of her own home — that's the lowest possible risk environment she could be in. Especially a home like this, set back from the road and having a good perimeter around it," Clemente told Fox News Digital. "So that means that to invade that privacy and security, that's the highest risk for an offender. So this is a very high-risk crime on a very low-risk victim, which means the motivation must have been greater than the risk that was taken by this offender."

Clemente emphasized that no motive is known, but addressing reports of a ransom note sent to several news outlets, said money could play a role.

More broadly, he said that motives in kidnappings and abductions can also include personal ideology and sex crimes.

"We don't know what the motive is, but we do know that it was a very high motivation because [the perpetrator] overcame such a high risk," he said.

"The next thing is, they removed her from the home, and typically, that only happens when an offender has some known connection to the home, or to the victim, or both. And that could be because he, or they, worked at the home, doing some repairs, caring for the garden, the pool, whatever it is. But some connection that would give them the information that she lived there alone, and that she was vulnerable."

While internet sleuths were quick to notice that an agent wearing a patch for the Internet Crimes Against Children task force was pictured outside the house of Nancy Guthrie's daughter, Annie, former FBI agent Nicole Parker tells Fox News Digital that’s not the important part of the images.

They show him carrying a Cellebrite case — likely containing equipment from the company known for extracting evidence from electronic devices like smart phones and computers.

He was seen arriving about a half-hour before investigators brought what appeared to be video equipment into the home. Later that evening, the Guthries released a video telling the author of a purported ransom note they were ready to talk and pleading for proof of life showing Nancy Guthrie.

Jason Pack, a retired FBI supervisory special agent and hostage negotiator, told “FOX & Friends First” on Thursday that a video released by Savannah Guthrie and her siblings “does two things – it opens that line of communication to the hostage takers or taker and it also implores that person or people to take care of Mrs. Nancy.” 

“They want to make sure things are slow and methodical, but they also know that she needs her medicine and needs some care,” Pack said regarding the video plea for missing Nancy Guthrie. 

When asked about the authenticity of a possible ransom note in the case, Pack said, “That’s a great question and I think that's a question that investigators behind the scenes and privately are still trying to vet. 

“But since they haven’t heard from anybody, they want to make sure that they are treating this lead, or this note, or these notes with as much authenticity as possible until they can prove it otherwise,” Pack said. “Because you wouldn’t want to sit on something and not act on it if there is a possibility that it could be true.” 

Pima County Sheriff Chris Nanos previously said that missing Nancy Guthrie had dinner with her daughter Annie and son-in-law, Tommaso Cioni, on Saturday evening, Nanos told The New York Times.

He added that Cioni dropped Nancy Guthrie off at her home afterward and made sure she made it inside.

Fox News Digital drove the shortest and likely route Nancy Guthrie took home with her family Saturday night — the last time she was seen alive.

Nanos said Nancy Guthrie didn't attend her Sunday church service, adding that her family was notified about the absence by a churchgoer. Officials said family members went to Nancy Guthrie's home at around 11 a.m. and spent some time looking for her. Her family called 911 at around noon to report her missing.

Ed Smart, the father of kidnapping survivor Elizabeth Smart, told “FOX & Friends” on Thursday that Nancy Guthrie’s family “wants to the keep the information flowing” with the release of their video making a plea for her return. 

“It wants to also let her mother know that bring her hope... that they haven't forgotten her, that they're trying to do everything that they possibly can to bring her home,” Smart said. 

“I think also talking directly to those that have taken her, the abductors, is crucially important that they know that they're trying to comply with everything that's being said, that they want to resolve this and bring their mother home,” he continued. 

“You know in our case, we know we wanted to let Elizabeth know that we were thinking of her, that we are there for her, that she's not being forgotten. And you know the support from the community is huge,” Ed Smart also said. 

Smart told “FOX & Friends” that, “There are a lot of questions that remain unanswered to the public.” 

“But we know that law enforcement generally have an idea of what's going on. And, that, you know, the most current information is something that only they would know,” he said. 

Former assistant SWAT team leader Chad Ayers told “FOX & Friends” on Thursday that he believes the FBI will be looking at “anybody and everything at this point” in the search for missing Nancy Guthrie. 

Ayers made the remark after Savannah Guthrie and her siblings released a video in which they made an emotional public plea for their missing mother. He was asked by co-host Brian Kilmeade, “is it safe to say that if we watch three family members give this plea to the would-be captors, that they've been eliminated as suspects? 

“I wouldn't go that far. I mean, this almost goes back to the Susan Smith case... where she, you know, I think they already knew that she was a suspect. They let her get on the media and give the plea. Where's my kids? Who did this to my kids? So I wouldn't say that's 100% correct,” Ayers responded,” referring the South Carolina mother who killed her two young sons in 1994.  

“I think the bureau is going to look at anybody and everything at this point,” Ayers added. 

The man leading the investigation into the high-profile disappearance of 84-year-old Nancy Guthrie, the mother of NBC "Today" host Savannah Guthrie, is an experienced law enforcement officer with a half-century of experience under his belt.

According to this official biography, Pima County, Arizona Sheriff Chris Nanos has been an officer of the law since 1976, beginning his career with the El Paso Police Department in Texas. In 1984, he became a corrections officer in Pima County, and the next year was promoted to deputy.

In the 30 years that followed, he focused on violent crimes, sex crimes and narcotics interdiction as he rose through the ranks of the department. He became chief of the department's investigative bureau in 2012, and in 2014, he became chief deputy.

TUCSON, Ariz. – NBC "Today" co-host Savannah Guthrie and her siblings made an emotional public plea on Instagram for their missing mother, Nancy Guthrie, urging anyone who may have abducted the 84-year-old to make contact as Arizona investigators say evidence suggests a crime and reports of a possible ransom demand have surfaced.

Savannah Guthrie opened the family’s plea by thanking supporters for their prayers before describing her mother as the heart of their family and making a direct appeal for contact, stressing Nancy Guthrie’s fragile health and urgent need for medication.

"Our mom is a kind, faithful, loyal, fiercely loving woman of goodness and light," Savannah Guthrie said. "She’s funny, spunky. She has grandchildren that adore her and crowd around her and cover her with kisses. She loves fun and adventure. She is a devoted friend. She is full of kindness and knowledge. Talk to her and you’ll see."

"Our mom is our heart and our home. Her health, her heart is fragile," she continued. "She is without any medicine. She needs it to survive. She needs not to suffer. We, too, have heard the reports about a ransom letter in the media. As a family, we are doing everything that we can.

"We are ready to talk. However, we live in a world where voices and images are easily manipulated," she added. "We need to know without a doubt that she is alive and that you have her. We want to hear from you, and we are ready to listen. Please reach out to us."

President Donald Trump also offered a major helping hand in the search for Nancy Guthrie on Wednesday night.

"I spoke with Savannah Guthrie, and let her know that I am directing ALL Federal Law Enforcement to be at the family’s, and Local Law Enforcement’s, complete disposal, IMMEDIATELY," he wrote on Truth Social. "We are deploying all resources to get her mother home safely. The prayers of our Nation are with her and her family. GOD BLESS AND PROTECT NANCY!"

Fox News Digital's Michael Ruiz and Greg Wehner contributed to this report.

TUCSON, Ariz. – Officials in Tucson, Arizona, are continuing to search for the mother of NBC "Today" co-host Savannah Guthrie after she went missing from her home and was last seen on Saturday night, saying that a crime has been committed.

Nancy Guthrie, 84, was last seen at her Tuscon residence at around 9:30 p.m. Saturday, according to the Pima County Sheriff's Department. While officials didn't immediately elaborate on the circumstances of her disappearance, Sheriff Chris Nanos said on Monday that "we do, in fact, have a crime."

A spokesperson for the Pima County Sheriff's Office told Fox News Digital that it's believed Nancy Guthrie was either kidnapped or abducted.

"Sheriff [Chris] Nanos has stated that he believes that a crime has been committed," a spokesperson for Pima County Sheriff’s Office told Fox News Digital. "At this point, investigators believe she was taken from the home against her will and that includes possible kidnapping or abduction."

Nanos said Nancy Guthrie didn't leave the home by herself. According to the Los Angeles Times, blood was found inside Nancy Guthrie's home. A law enforcement source told Fox News Digital that there were "blood drops" leading from the entryway outside down the house's pathway towards the driveway.

During an interview on MSNOW on Tuesday, Nanos said Nancy Guthrie was "physically removed from that home against her will," but declined to say whether she was harmed. The sheriff also said it's unknown if the individual who took Nancy Guthrie is familiar or a stranger.

Click here for a timeline of events in the disappearance of Nancy Guthrie.

Fox News Digital's Adam Sabes, Christina Dugan Ramirez and Sarah Rumpf-Whitten contributed to this report.